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Recent studies implicate mtDNA depletion via TFAM mutation in fostering tumor progression as well as cisplatin resistance in microsatellite instability (MSI) CRC, with implications yet to be fully explored in microsatellite stable CRC (175) ( Table 4 )

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Liv had the mole removed but was diagnosed with stage one melanoma that required surgery and left her with a scar the size of a letterbox on her leg

These findings have general implications for the use of roGFP2-based redox probes: as sulfane sulfur species can oxidize roGFP2-Orp1 in an Orp1-independent manner, it is important to compare fused and unfused roGFP2 probes in side-by-side experiments to distinguish between Orp1-dependent and Orp1-independent roGFP2 oxidation events (as demonstrated in Fig